Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression and cognitive resilience
Zunpeng Liu, Shanshan Zhang, ..., Lei Huang, ..., Manolis Kellis
Selected Publications
Research across molecular generation, drug-target modeling, and single-cell biology.
A focused selection of papers that best represent my work in AI for drug design, biomedical machine learning, and computational biology.
Recent and representative
Selected Publications
A versatile informative diffusion model for single-cell ATAC-seq data generation and analysis
Lei Huang, Lei Xiong, Na Sun, Zunpeng Liu, Ka-Chun Wong, Manolis Kellis
A dual diffusion model enables 3D binding bioactive molecule generation and lead optimization given target pockets
Lei Huang, Tingyang Xu, Yang Yu, Peilin Zhao, Ka-Chun Wong, Hengtong Zhang
DiffDTM: A conditional structure-free framework for bioactive molecules generation targeted for dual proteins
Lei Huang, Zheng Yuan, Huihui Yan, Rong Sheng, Linjing Liu, Fuzhou Wang, Weidun Xie, Nanjun Chen, Fei Huang, Songfang Huang, Ka-Chun Wong, Yaoyun Zhang
ProteinRPN: Towards Accurate Protein Function Prediction with Graph-Based Region Proposals
Shania Mitra, Lei Huang (co-first author), Manolis Kellis
Enabling Single-Cell Drug Response Annotations from Bulk RNA-Seq Using SCAD
Zetian Zheng, Junyi Chen, Xingjian Chen, Lei Huang, Weidun Xie, Qiuzhen Lin, Xiangtao Li, Ka-Chun Wong
MDM: Molecular Diffusion Model for 3D Molecule Generation
Lei Huang, Hengtong Zhang, Tingyang Xu, Ka-Chun Wong
CoaDTI: Multi-modal co-attention based framework for drug-target interaction annotation
Lei Huang, Jiecong Lin, Rui Liu, Zetian Zheng, Lingkuan Meng, Xingjian Chen, Xiangtao Li, Ka-Chun Wong
EGFI: Drug-Drug Interaction Extraction and Generation with Fusion of Enriched Entity and Sentence Information
Lei Huang, Jiecong Lin, Xiangtao Li, Linqi Song, Zetian Zheng, Ka-Chun Wong